A study on the cause and treatment of knee osteoarthritis

Advertisement Osteoarthritis is a chronic long-term disease.

A study on the cause and treatment of knee osteoarthritis

Although there is no cure, numerous treatments are available to reduce symptoms, including over-the-counter and prescription drugs.

A study on the cause and treatment of knee osteoarthritis

Exercising and losing weight if a patient is overweight or obese also can help. So, which treatment is best? To help sort out the choices, a group of researchers set out to assess how the available non-surgical drug treatments stack up against each other for providing pain relief and improving physical function.

The authors did not address lifestyle changes, like weight loss and exercise. Ranking the Options The researchers used a technique called network meta-analysis to analyze and rank the results of 56 studies comparing two or more of the following intra-articular injected into a joint and oral treatments: After crunching the numbers, researchers found naproxen was ranked first compared with all the other treatments for improving both pain and function followed by IA corticosteroid, IA platelet-rich-plasma, celecoxib and ibuprofen.

Naproxen was also ranked first for improving function alone followed by diclofenac, celecoxib, ibuprofen and IA platelet-rich plasma.

Osteoarthritis Research | Causes of Osteoarthritis

And IA corticosteroid injection was ranked first for alleviating pain alone followed by ibuprofen, IA platelet-rich plasma, naproxen and celecoxib. Some work better than others. Some work well for pain, and some work well for function. Our study showed that naproxen works best for both pain and function, and it is one of the least expensive nonsteroidal anti-inflammatory drugs.

While some guidelines recommend this controversial treatment for knee OA, others are neutral and some recommend against it. Acetaminophen ranked near the bottom of the list of treatments for pain and function. One is that the researchers did not describe how well each treatment worked on its own.

Instead, the study ranked the treatments as they compared to one another, creating a hierarchy from most to least effective treatments.

They also did not go into any detail on side effects. For example, well-known side effects of nonsteroidal anti-inflammatory drugs NSAIDs — like ibuprofen, diclofenac, celecoxib and naproxen — include cardiovascular and gastrointestinal problems.

Guidelines Can Help Doctors Choose the Best OA Treatments. The American College of Rheumatology issued new recommendations for knee and hip osteoarthrits treatment, and its first-ever for hand OA. "Knee osteoarthritis is a leading cause of disability in the U.S. and women have greater pain and reductions in function and quality of life from this condition than do men," said researcher Mary I. O'Connor, MD, chair of the Department of Orthopedic Surgery at Mayo Clinic's campus in Florida. Oct. 5 (UPI) --New research with rats and human tissue samples may lead to a treatment for people with knee and spine osteoarthritis based on a newly found molecular target.

Furthermore, two of the most effective interventions, weight loss and exercise, were not included in the comparison. Treatment for knee OA should be individualized for each patient. This article did not discuss other effective and recommended nonpharmacologic approaches such as exercise and weight loss.

Silverman says, adding that he uses pharmacologic management to enable his patients to do exercise to improve function and lose weight.While age is a major risk factor for osteoarthritis of the knee, young people can get it, too.

For some individuals, it may be hereditary. For some individuals, it may be hereditary. Oct. 5 (UPI) --New research with rats and human tissue samples may lead to a treatment for people with knee and spine osteoarthritis based on a newly found molecular target.

Factors that may increase your risk of osteoarthritis include: Older age. The risk of osteoarthritis increases with age. Sex.

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Women are more likely to develop osteoarthritis, though it isn't clear why. Obesity. Carrying extra body weight contributes to osteoarthritis in several ways, and the more you weigh, the greater your risk.

Knee osteoarthritis is the most common form of osteoarthritis. More than 10 million Americans have knee osteoarthritis. It is also the most common cause of musculoskeletal disability in the United States.

Successful management of knee osteoarthritis depends on recognizing early symptoms, an accurate diagnosis, and appropriate treatment. Current treatments include physical therapy, non-steroidal anti-inflammatory medications, viscosupplement injections, and total knee replacement.

The American Academy of Orthopaedic Surgeon’s (AAOS) guidelines for the treatment of osteoarthritis of the knee note that there were few non-surgical treatments that could be recommended. A new study takes a look at which approaches are best to bring relief to people with knee osteoarthritis (OA), a condition that affects approximately 20 percent of people over the age of 45 in the United States..

Knee OA can be extremely painful and limit a person’s ability to function.

Study looks for gender differences in osteoarthritis occurrence